1. Damage to sensory area 1 of the cerebral cortex results in

a) Loss of perception of pain

b) Loss of tactile and two-point discrimination

c) Loss of perception of touch

d) Loss of only tactile discrimination



2. Volume of CSF is about

a) 50ml

b) 100ml

c) 150 ml

d) 200 ml



3.Dissymmetria is seen in

a) Extra pyramidal lesions       

b) Cerebellar lesions

c) Pyramidal lesions

d) Cortical lesions



4.Floculonodular lobe of cerebellum is concerned with

a) Equilibrium

b) Co-ordination

c) Baroreception

d) Chemoreception



5.In the postnatal period the greatest growth in the grey matter of the C.N.S is of 

a) Neuron cell number    

b) Length of axon      

c) Dendritic tree

d) Size of Perikaryon



6.CSF production per minute

a) 0.30-0.35 ml/min



d) 1 ml/min



7.Function of GABA on CNS is

a) Neuronal inhibition    

b) Neuronal activation    

c) Glial cell inhibition     

d) Glial cell activation



8.The EEG rhythm having lowest frequency is:

a) Alpha

b) Beta

c) Delta

d) Theta



9.Medial geniculate body is concerned with

a) Hearing

b) Vision

c) Smell

d) Taste



10.True statement regarding CSF is

a)Daily production < 700 ml

b)CSF analysis rules out active secretion as a cause of formation of CSF

c)It flows from III ventricle to the IV ventricle

d) Produced only by choroid plexus



11. In cerebellar disease, all the statements are correct except

a) The Romberg's sign is positive

b) There is Adiodokokinesia

c) There is pendular knee jerk

d) There is involuntary tremor




12.Swallowing center is situated in

a) Midbrain

b) Pons

c) Medulla

d) Cerebellum




13.Hyper kinetic syndromes such as chorea and athetosis are usually associated with

    pathological changes in:

a) Motor areas of cerebral cortex

b) Anterior hypothalamus

c) Pathways for recurrent collateral inhibition in the spinal cord     

d) Basal ganglia complex




14. An EEG:

a)Provides indication of intelligence

b)Tends to show waves of smaller amplitude during deep sleep than of alert state

c)Show waves with a lower frequency during intense thought than during sleep

d)Is bilaterally symmetrical




15.The following is true about brain metabolism except

a) Use fatty acid in starvation

b) In resting state 60% of total energy utilized

c) Ketone bodies are used in starvation

d) Has no energy store




16.Satiety center in hypothalamus is regulated by:

a) Gastric dilatation 

b) Blood glucose levels     

c) Blood insulin leve

d) All of the above




17. In hippocampus EEG waves are

a) Alpha wave

b) Beta wave

C) 65 mm of Hg





18.EEG with spike and dome pattern is characteristic of epilepsy

a) Jacksonian

b) Grandmal

c) Petitmal

d) Temporal lobe 





19.Buerger waves (alpha waves) of EEG have the rhythm per sec of:

a) 0-4



d) 13-30




20.All the following are more in CSF compared to plasma except




d) Glucose




21. During light sleep, the sleep spindles that appear have the frequency of:

a) 1 -2/sec

b) 6-12/sec

c) 14-16/sec

d) 21 -26/sec




22.Up to what systolic pressure is the brain capable of auto regulation

a) Dorsomedian nucleus of hypothalamus

b) Ventromedian nucleus of hypothalamus 

c) Perifornical region

d) 75mmofHg




23. pH of CSF is: 

a) 7.13

b) 7.23

c) 7.33

d) 7.40




24.Temporal lobe lesion causes:

a) Homonymous upper quadrantinopia 

b) Homonymous lower quadrantinopia

c) Bitemporal hemianopia

d) Binasal hemianopia




25.Hyperphagia results from lesion of

a) Thalamus

b) Cerebral cortex

c) Ventromedial region of supra-optic nucleus

d) Ventrolateral region of supra-optic nucleus




26.  Delta waves in EEG are seen in

a) Deep sleep

b) REM sleep       

c) Awake with eyes open

d) Awake with eyes closed




27. Nightmares are seen in

a) REM sleep

b) NREM stage II

c) NREM stage III

d) NREM stage IV




28.  Which of the following are true of median eminence

a) Portion of ventral hypothalamus

b) Hypothalamo hypophyseal vessels arise here

c) Outside the blood-brain barrier

d) All are correct




29.  Unconscious kinesthetic sensations are carried by

a) Posterior columns

b) Ventral spinothalamic tract

c) Anterior spinothalamic tract

d) Lateral spinothalamic tract




30. Crossed extensor reflex is a

a) Withdrawal reflex     

b) Postural reflex

c) Monosynaptic reflex     

d) Sympathetic reflex




31.Renshaw cell inhibition is an example of

a) Feed-forward inhibition

b) Oscillating motor activity

c) Circuitry for bio feedback

d) All of the above




32.Arousal response is mediated by

a) Dorsal column

b) Reticulo activating system

c) Spinothalamic tract

d) Vestibulo cerebellar tract




33.All are seen in a spinal reflex except

a) Summation

b) Fatigue

c) Memory

d) Adaptation




34.First change to occur in the distal segment of cut nerves

a) Myelin degeneration

b) Axonal degeneration

c) Mitosis of Schwann cell

d) Sprouting




35.Maximum increase in pain threshold occurs in which phase of sleep

a) Phase I

b) Phase 3

c) Phase 4

d) REM sleep




36.Below pressure, CSF absorption stops








37.Phagocytosis in the CNS is done by

a) Astrocytes

b) Schwann cells

c) Microglia

d) Oligocytes




38.The condition known as REM sleep is:

a)That point at which the individual becomes aware and alert

b)Referred to paradoxical sleep

c) Characterized by total lack of all muscular activity 

d) Characterized by slow high voltage regular EEG activity




39.Gag reflex is mediated by cranial nerve:








40.Hypertonia indicates

a) Upper motor neuron injury 

b) Lower motor neuron injury 

c) Cerebellar lesion

d) Autonomic imbalance




41.What is not true for respiration center?

a)Situated in the medulla and pons

b)Sends out regular bursts of impulses to expiratory muscles during quiet respiration

c)sends out regular impulses to expiratory muscles during quiet respiration

d)Is inhibited during swallowing and vomiting




42.In brain ischaemia, systemic blood pressure rises, this is called:

a) Monro-kellie doctrine

b) Cushing reflex

c) Auto regulation      

d) White reaction




43.Vestibular fibers relay in

a) Vermis

b) Lateral geniculate body

c) Floculonodular lobe of cerebellum

d) Auditory cortex




44Vomiting center is situated in the

a) Hypothalamus     

b) Amygdala

c) Pons

d) Medulla




45. Broca's area

a) Is situated in temporal lobe 

d) It is synonymous to Wernicke's area

c) Is an area of hearing

b) Is supplied by middle cerebral artery 




46.Crude touch sensations are carried by

a) Lateral spinothalamic tract

b) Posterior columns

c) Ventral spinothalamic tract

d) P)tramidal tract




47.One of the following is a function of hypothalamus

a) Swallowing

b) Vomiting

c) Respiration      

d) Homeostasis of temperature




48.Blood brain barrier is maximum permeable to:



c) Chloride





49.The basic postural reflex is

a) Crossed extensor reflex      

b) Golgi tendon reflex   

c) Flexor reflex   

d) Positive supporting reflex




50.All of the following manifestations are seen in cases of cerebellar damage in human beings except

a) Loss of non-declarative/reflexive memory      

b) Loss of adjustment of ve9tibulo-ocular reflex

c)Static tremor and rigidity

d) Ataxia, atonia and asthenia




51.Which of the following reflexes disappear in the absence of functional connections between  the spinal cord and the brain?

a) Swallowing reflex

b) Seating reflex                          

c) Withdrawal reflex

d)Erection of penis

e) All of the above




52. In the Neurohypophysis, secretory granules accumulate in:

a) Pituicytes

b) Nerve endings

c) Intercellular spaces

b) Association fibers




53.  Conduction in which type of nerve fibers is blocked maximally by pressure

a) C fibers

b) A-alpha fibers






54.Prosapagnosia is

a) Inability to recognize faces    

b) Inability to draw

c) Inability to count

d) Inability to smell




55. Pain sensitive part in CNS is

a) Durameter

b) Piameter

c) Brain

d) Pial vessels




56.Wallenberg degeneration is seen in

a) Proximal cut end of nerve with cell body 

b) Distal cut end of nerve without cell body 

c) Both the free ends of the cut nerve

d) All are true




57.When sensory area-I of the cerebral cortex is ablated

a) Perception of pain is completely abolished     

b) Perception of touch is completely abolished

c)There is loss of tactile localization but two point discrimination is not bolished

d)There is loss of tactile discrimination as well as two-point discrimination




58.Injection of hypertonic saline into which area causes diuresis

a) Supraoptic nucleus

b) Paraventricular nucleus

c) Preoptic nucleus

d) Posterior pituitary




59.A unilateral upper motor neuron lesion in the internal capsule is best characterized by

a)Diminished use of contra lateral appendages below the lesion

b)Muscle fasciculations        

c)Ipsilateral hypotonicity




60. Source of EEG

a) A potential of pyramidal cells

b) A potential of ganglion cells

c)EPSP and IPSP of cortical cells which behave like dipoles

d)After potentials of parietal cortex




61. Decerebrate animal results from the following experimental procedure:

a) Removal of the cerebrum

b) Tran section at the upper border of midbrain

c) Inter collicular transection

d) Section above the thalamus




62.CSF pressure (lumbar)




d) 150-250 mm CSF




63.Which of the foUowing sensation is not carried through posterior column?

a) Touch

b) Proprioception

c) Visceral pain

d) All of the above




64. Stereo anesthesia is due to lesion of

a) Nucleus Gracillis     

b) Nucleus cuneatus       

c) Spinoreticular tract

d) Subarachnoid space




65.Broca's area is present in

a) Superior temporal Gyrus     

b) Precentral gyrus     

c) Post central gyrus    

d)Inferior frontal gyrus




66.The cerebellum:

a)Has a totally inhibitory output from its cortex

b)Has only excitatory signal output from its deep nuclear layers

c)Has conscious interpretation of motor activity

d)Has inhibitory influence on muscle tone in humans




67.Hypothalamus regulates all except

a) Food intake          


c) Anticipatory rise in heart rate      

d) Hypophysis




68.Loss of feel of size & shape of a object is seen in lesions of

a)Tractus solitarius    

b) Tractus cuneatus     

c) Lateral spinothalamic tract    

d)Spinoreticular tract




67.The reticular formation is a diffuse collection of:

a) Only sensory neurons

b) Only motor.neurons

c) Only autonomic centers

d) All the above




68.CSF is principally secreted by

a) Choroid plexus     

b) Arachnoid granulation   

c) Floor of fourth ventricle   

d)Periaqueductal grey




69.Paralysis agitans is accompanied by imbalance of neurotransmitter contents in

a) Globus pa'llidus and substantia nigra

b) Locus ceruleus

c) Putamen

d) Caudate nucleus and subthalamic body



70.In Rrown-Sequard syndrome sensation, that is lost at the same side of lesion is

a) Pain

b) Touch

c) Temperature

d) Proprioception